“Maximizing the Benefits of Kratom: The Use of Potentiators”

March 11, 2023

Mitragyna Speciosa

Kratom, also known as Mitragyna speciosa, is a tropical evergreen tree that is native to Southeast Asia. It’s leaves have been traditionally used for medicinal purposes such as pain relief, improved mood, and increased energy. However, many users have found that by adding certain substances, called potentiators, to their kratom regimen, they can enhance and prolong the effects of kratom. In this blog post, we will explore the various potentiators of kratom and their uses, as well as the potential risks and benefits.

Four Potentiators

One popular potentiator of kratom is turmeric. Turmeric contains the active ingredient curcumin, which has been shown to enhance the effects of kratom by increasing the bioavailability of the alkaloids in the plant (Sharma et al, 2012). Turmeric can be consumed in supplement form or added as a spice to food.

Another potentiator is magnesium. Magnesium is a mineral that is essential for many bodily functions, including muscle and nerve function, blood sugar control, and blood pressure regulation. Magnesium supplements have been found to increase the effects of kratom by improving the body’s ability to absorb the alkaloids (Russo, 2011).

Grapefruit is also often used as a potentiator for kratom. The compounds found in grapefruit, called furanocoumarins, have been shown to increase the bioavailability of certain drugs, including kratom (FDA, 2019). Grapefruit can be consumed as a juice or in supplement form.

Caffeine is another potentiator that is commonly used in conjunction with kratom. Caffeine is a stimulant that can increase energy and alertness, which can enhance the effects of kratom. However, it’s important to note that caffeine can also increase the risk of side effects, such as jitteriness and anxiety (FDA, 2018).

Know your body

It’s important to note that while potentiators can enhance the effects of kratom, they can also increase the risk of side effects. Furthermore, it’s important to consult with a healthcare professional before using potentiators, particularly if you are taking any medication or have any underlying health conditions. Additionally, it’s important to note that most of the research on kratom potentiators is pre-clinical, so more research is needed to establish their true effects and potential risks.

In conclusion, potentiators can enhance the effects of kratom by increasing the bioavailability of its alkaloids. However, it’s important to use these substances with caution, as they can also increase the risk of side effects. Always consult with a healthcare professional before using any potentiators and consider the potential benefits and risks before starting any new supplement regimen.

For premium quality kratom products and extracts, visit KangaKratom.com, a trusted vendor offering a wide range of kratom options to enhance your kratom experience. Consult with their experts to find the ideal kratom products for your needs.


Sharma R, Kuttan G, Kuttan R. (2012). Curcumin as an inhibitor of cancer. Cancer letters, 323(1), 61-70.

Russo E. (2011). Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. British Journal of Pharmacology, 163(7), 1344-1364.

-Tiffany King

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